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Beta-blockers not effective after MI when ejection fraction is preserved

  • 2 hours ago
  • 1 min read

The benefit of beta‑blockers after myocardial infarction in patients with preserved left ventricular ejection fraction (LVEF ≥50%) is uncertain. This individual‑patient meta‑analysis combined five open‑label randomised trials, including 17,801 patients without other indications for beta-blockers1. 


Participants were assigned to beta‑blocker therapy or no therapy, and the primary outcome was a composite of all‑cause death, myocardial infarction, or heart failure. After a median 3.6‑year follow‑up, primary events occurred in 8.1% of the beta‑blocker group and 8.3% of the control group (hazard ratio 0.97; 95% CI 0.87–1.07). Rates of death, myocardial infarction, and heart failure were also similar between groups.

 Overall, beta‑blockers did not reduce major clinical events in post‑MI patients with preserved LVEF and no other therapeutic indication.


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