Cardiometabolic issues with antidepressants
- admin82291
- 5 hours ago
- 1 min read
A systematic review in The Lancet1 outlined the cardiometabolic issues with antidepressants.There were a few surprises:
None had significant QT interval issues.
Systolic BP went up with amitriptyline and fluoxetine and down with nortriptyline.
Weight loss was observed with bupropion, sertraline, citalopram, paroxetine, and venlafaxine.
Weight gain was found with amitriptyline 1.6 kg and mirtazapine 0.87 kg.
Heart rate increased (beats per minute) to 13.77 for nortriptyline, 9.25 for amitriptyline, and 9.44 for imipramine.
Reference:
The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis The Lancet (2025)
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