Isolated diastolic hypertension: No benefit in treatment

This meta-analysis included pooled data from 51 trials involving 358,325 participants, of whom 4.4% had isolated diastolic hypertension (IDH)¹. 

Over 4.2 years, reducing systolic pressure by 5 mmHg lowered major cardiovascular events to a similar degree in people with and without IDH. Treatment effects did not vary by baseline diastolic pressure, cardiovascular history, age, prior medication, or measurement method. 

The study found no evidence that BP-lowering therapy is more, or less effective in IDH compared with other groups, and benefits did not diminish at lower diastolic pressures.

Reference:

Blood pressure lowering in isolated diastolic hypertension and cardiovascular risk: an individual patient data meta-analysis Eur Heart J. (2025)

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